MS4078 | ALK PROTAC | Probechem Biochemicals

Chemical Structure : MS4078

CAS No.: 2229036-62-6

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MS4078 (MS-4078, MS 4078)

货号: PC-63528Not For Human Use, Lab Use Only.

MS4078 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=11 nM).

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5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
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生物&药学活性

MS4078 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=11 nM).
MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism, potently inhibits proliferation of SU-DHL-1 cells with IC50 of 33 nM.

物理化学性质&存储条件

分子量	914.476
分子式	C45H52ClN9O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide

参考文献

1. Zhang C, et al. Eur J Med Chem. 2018 May 10;151:304-314.

MS4078 (MS-4078, MS 4078)

生物&药学活性

物理化学性质&存储条件

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MS4078 (MS-4078, MS 4078)

生物&药学活性

物理化学性质&存储条件

参考文献

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