MS159 | NSD2 PROTAC | Probechem Biochemicals

Chemical Structure : MS159

CAS No.: 3031353-59-7

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MS159 (MS 159)

货号: PC-49208Not For Human Use, Lab Use Only.

MS159 is a first-in-class NSD2 proteolysis targeting chimera (PROTAC) degrader of nuclear receptor binding SET domain protein 2 (NSD2), also effectively degrads CRBN neo-substrates IKZF1 and IKZF3, but not GSPT1.

规格	价格	库存
1 mg	￥2980	In stock
5 mg	￥5980	In stock
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25 mg		Get quote

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生物&药学活性

MS159 is a first-in-class NSD2 proteolysis targeting chimera (PROTAC) degrader of nuclear receptor binding SET domain protein 2 (NSD2), also effectively degrads CRBN neo-substrates IKZF1 and IKZF3, but not GSPT1.
MS159 effectively degrades NSD2 in a concentration-, time-, CRBN-, and proteasome-dependent manner.
MS159 is much more effective in suppressing the growth in cancer cells than the parent NSD2 binder UNC6934.
MS159 is bioavailable in mice and is a valuable chemical tool for exploring the roles of NSD2 in health and disease.

物理化学性质&存储条件

分子量	828.839
分子式	C43H40N8O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-cyclopropyl-N-(4-((5-(3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)propoxy)pyridin-2-yl)carbamoyl)benzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide

参考文献

1. Meng F, et al. J Med Chem. 2022 Jul 27. doi: 10.1021/acs.jmedchem.2c00807.

MS159 (MS 159)

生物&药学活性

物理化学性质&存储条件

参考文献

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MS159 (MS 159)

生物&药学活性

物理化学性质&存储条件

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