MS-377 |CAS:206862-30-8 Probechem Biochemicals

Chemical Structure : MS-377

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MS-377 (MS377)

货号: PC-63205Not For Human Use, Lab Use Only.

MS-377 is a potent, selective sigma-1 receptor ligand with Kd of 15.2 nM, showed anti-phencyclidine (PCP), anti-dopaminergic and anti-serotonergic activities.

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MS-377 is a potent, selective sigma-1 receptor ligand with Kd of 15.2 nM, showed anti-phencyclidine (PCP), anti-dopaminergic and anti-serotonergic activities.
MS-377 markedly increases dopamine and serotonin release in the medial prefrontal cortex, significantly attenuates the effect of PCP in rat brain.

物理化学性质&存储条件

分子量	351.875
分子式	C18H26ClN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(4-chlorophenyl)-3-((4-(2-methoxyethyl)piperazin-1-yl)methyl)pyrrolidin-2-one

参考文献

1. Takahashi S, et al. Psychopharmacology (Berl). 1999 Aug;145(3):295-302.

2. Karasawa J, et al. Eur J Pharmacol. 2000 Jul 14;400(1):51-7.

3. Yamada S, et al. Eur J Pharmacol. 2000 Aug 25;402(3):251-4.

4. Takahashi S, et al. Eur J Pharmacol. 2001 Sep 21;427(3):211-9.

MS-377 (MS377)

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物理化学性质&存储条件

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MS-377 (MS377)

生物&药学活性

物理化学性质&存储条件

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