MPD2 | SARS-CoV-2 Mpro PROTAC | Probechem Biochemicals

Chemical Structure : MPD2

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MPD2 (SARS-CoV-2 Mpro degrader MPD2)

货号: PC-22155Not For Human Use, Lab Use Only.

MPD2 is a first-in-class PROTAC degrader of SARS-CoV-2 MPro, effectively reduces MPro protein levels in 293T cells with DC50 of 296 nM on a time-dependent, CRBN-mediated, and proteasome-driven mechanism.

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生物&药学活性

MPD2 is a first-in-class PROTAC degrader of SARS-CoV-2 MPro, effectively reduces MPro protein levels in 293T cells with DC50 of 296 nM on a time-dependent, CRBN-mediated, and proteasome-driven mechanism.
MPD2 exhibits promising antiviral activity against various SARS-CoV-2 strains and exhibiting enhanced potency against nirmatrelvir-resistant viruses.

物理化学性质&存储条件

分子量	973.13
分子式	C51H68N6O13
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)oxy)benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate

参考文献

1. Alugubelli YR, et al. J Med Chem. 2024 Apr 12. doi: 10.1021/acs.jmedchem.3c02416.

MPD2 (SARS-CoV-2 Mpro degrader MPD2)

生物&药学活性

物理化学性质&存储条件

参考文献

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MPD2 (SARS-CoV-2 Mpro degrader MPD2)

生物&药学活性

物理化学性质&存储条件

参考文献

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