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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-MMV1580853
MMV1580853

Chemical Structure : MMV1580853

CAS No.: 5352-53-4

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MMV1580853 (BPH-1358, MMV 1580853)

货号: PC-22743Not For Human Use, Lab Use Only.

MMV1580853 (BPH-1358) is a potent and exceedingly fast-acting blood-stage antimalarial, inhibits human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively.

规格 价格 库存 数量
5 mg ￥2380 In stock
10 mg ￥3880 In stock
25 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MMV1580853 (BPH-1358) is a potent and exceedingly fast-acting blood-stage antimalarial, inhibits human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively.

物理化学性质&存储条件

分子量 601.53
分子式 C32H30Cl2N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N4,N4'-bis(3-(4,5-dihydro-1H-imidazol-2-yl)phenyl)-[1,1'-biphenyl]-4,4'-dicarboxamide dihydrochloride

参考文献

1. Ryan Choi, et al. PLoS One. 2021 Apr 22;16(4):e0250019.

2. Zhu W, et al. J Med Chem. 2015 Feb 12;58(3):1215-27.

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