MMV1557817 | Aminopeptidase M1/M17 inhibitor | Probechem Biochemicals

Chemical Structure : MMV1557817

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MMV1557817 (MMV 1557817)

货号: PC-22373Not For Human Use, Lab Use Only.

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生物&药学活性

MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 (Ki=308/19 nM) and M17 (Ki=112/208 nM), demonstrates potent activity against asexual and sexual stage parasites.
MMV1557817 exhibits potent activity against P. falciparum asexual Pf3D7 with EC50 of 39 nM, kills the sexual stages of early (stages I–III), late (stages IV–V) and mature (stage V) gametocytes with IC50 of 99 nM, 309 nM, and 1474 nM, respectively.
MMV1557817 retains nanomolar range activity against drug-resistant and clinical isolates of P. falciparum and P. vivax.
MMV1557817 shows good selectivity, safety, ADME, and exposure properties and is active in vivo against the rodent malaria species Plasmodium berghei.

物理化学性质&存储条件

分子量	394.39
分子式	C20H21F3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro-[1,1'-biphenyl]-4-yl)ethyl)-3,3-dimethylbutanamide

参考文献

1. Edgar RCS, et al. mBio. 2024 May 8:e0096624.

MMV1557817 (MMV 1557817)

生物&药学活性

物理化学性质&存储条件

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MMV1557817 (MMV 1557817)

生物&药学活性

物理化学性质&存储条件

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