MMV084978 | PfAcAS inhibitor | Probechem Biochemicals

Chemical Structure : MMV084978

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MMV084978 (MMV 084978)

货号: PC-72540Not For Human Use, Lab Use Only.

MMV084978 (MMV 084978) is an antiplasmodial drug-like compound tageting Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS), directly and selectively inhibit PfAcAS activity in vitro with IC50 of 370 nM.

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生物&药学活性

MMV084978 (MMV 084978) is an antiplasmodial drug-like compound tageting Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS), directly and selectively inhibit PfAcAS activity in vitro with IC50 of 370 nM.
MMV084978 directly inhibits PfAcAS by preventing CoA and acetate binding.
MMV084978 demonstrated in vitro efficacy (P. falciparum Dd2 EC50=150 nM) with increased liver-stage potency (Pbluc EC50= 520 nM).
MMV084978 directly and selectively inhibit PfAcAS activity in vitro.

物理化学性质&存储条件

分子量	282.702
分子式	C10H7ClN4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N'-(4-chlorobenzoyl)-1,2,3-thiadiazole-4-carbohydrazide

参考文献

1. Robert L Summers, et al. Cell Chem Biol. 2022 Feb 17;29(2):191-201.e8.

MMV084978 (MMV 084978)

生物&药学活性

物理化学性质&存储条件

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MMV084978 (MMV 084978)

生物&药学活性

物理化学性质&存储条件

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