MMV019721 | PfAcAS inhibitor | Probechem Biochemicals

Chemical Structure : MMV019721

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MMV019721 (MMV 019721)

货号: PC-72539Not For Human Use, Lab Use Only.

MMV019721 (MMV019721) is an antiplasmodial drug-like compound tageting Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS), directly and selectively inhibit PfAcAS activity in vitro with IC50 of 73 nM.

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生物&药学活性

MMV019721 (MMV019721) is an antiplasmodial drug-like compound tageting Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS), directly and selectively inhibit PfAcAS activity in vitro with IC50 of 73 nM.
MMV019721 directly inhibits PfAcAS by preventing CoA binding.
MMV019721 has activity against blood-stage parasites in vitro (P. falciparum 3D7, EC50=460 nM) and against liver-stage P. berghei parasites (Pbluc EC50=2,000 nM).
MMV019721 directly and selectively inhibits PfAcAS activity in vitro.

物理化学性质&存储条件

分子量	437.957
分子式	C19H20ClN3O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-5-(N,N-diethylsulfamoyl)-N-(2-methylbenzo[d]thiazol-6-yl)benzamide

参考文献

1. Robert L Summers, et al. Cell Chem Biol. 2022 Feb 17;29(2):191-201.e8.

MMV019721 (MMV 019721)

生物&药学活性

物理化学性质&存储条件

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MMV019721 (MMV 019721)

生物&药学活性

物理化学性质&存储条件

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