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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-MMV006833
MMV006833

Chemical Structure : MMV006833

CAS No.: 701253-55-6

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MMV006833 (M-833)

货号: PC-22542Not For Human Use, Lab Use Only.

MMV006833 (M-833) is a small molecule inhibitor of PfSTART1 with EC50 of 1.1 uM for Pf 3D7, binds to PfSTART1(WT) with KD of 42 nM, inhibits ring-stage development of Plasmodium falciparum, prevents PfSTART1 from expanding the vacuole membrane encasing the parasite after red blood cell invasion, thereby blocking parasite growth.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MMV006833 (M-833) is a small molecule inhibitor of PfSTART1 with EC50 of 1.1 uM for Pf 3D7, binds to PfSTART1(WT) with KD of 42 nM, inhibits ring-stage development of Plasmodium falciparum, prevents PfSTART1 from expanding the vacuole membrane encasing the parasite after red blood cell invasion, thereby blocking parasite growth.

物理化学性质&存储条件

分子量 414.95
分子式 C19H27ClN2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-chloro-2-methyl-5-(pyrrolidin-1-ylsulfonyl)phenoxy)-N-cyclohexylacetamide

参考文献

1. Madeline G Dans, et al. Nat Commun. 2024 Jun 18;15(1):5219.

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