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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-MMV000848
MMV000848

Chemical Structure : MMV000848

CAS No.: 539806-42-3

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MMV000848 (MMV 000848)

货号: PC-23029Not For Human Use, Lab Use Only.

MMV000848 is a small molecule inhibitor of P. falciparum purine nucleoside phosphorylase (PfPNP, KD=1.52 uM) with EC50 of 0.1 uM against Plasmodium falciparum, also inhibits falcilysin (FLN) proteolytic activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MMV000848 is a small molecule inhibitor of P. falciparum purine nucleoside phosphorylase (PfPNP, KD=1.52 uM) with EC50 of 0.1 uM against Plasmodium falciparum, also inhibits falcilysin (FLN) proteolytic activity.

物理化学性质&存储条件

分子量 308.43
分子式 C20H24N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol

参考文献

1. Chung Z, et al. J Biol Chem. 2024 Jan;300(1):105586.

2. Wirjanata G, et al. Cell Chem Biol. 2024 Apr 18;31(4):743-759.e8.

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