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首页-抗体药物偶连体和PROTACs-PROTAC-MMH2
MMH2

Chemical Structure : MMH2

CAS No.:

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MMH2 (BRD4 degrader MMH2)

货号: PC-22823Not For Human Use, Lab Use Only.

MMH2 is a potent, selective, covalent JQ1-derived PROTAC degrader of BRD4 via DCAF16 (BRD4BD2, DC50=1 nM, Dmax=95%), functions as a molecular glue to recruit DCAF16 selectively to BRD4 BD2, causing degradation of BRD4.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MMH2 is a potent, selective, covalent JQ1-derived PROTAC degrader of BRD4 via DCAF16 (BRD4BD2, DC50=1 nM, Dmax=95%), functions as a molecular glue to recruit DCAF16 selectively to BRD4 BD2, causing degradation of BRD4.

物理化学性质&存储条件

分子量 527.66
分子式 C25H29N5O4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

tert-butyl (S)-2-(2,3,9-trimethyl-4-(4-(vinylsulfonamido)phenyl)-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

参考文献

1. Li YD, et al. Nat Chem Biol. 2024 Jul 29. doi: 10.1038/s41589-024-01668-4.

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