MMH1 | BRD4 degrader | Probechem Biochemicals

Chemical Structure : MMH1

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MMH1 (BRD4 degrader MMH1)

货号: PC-22822Not For Human Use, Lab Use Only.

MMH1 is a potent, selective, covalent JQ1-derived PROTAC degrader of BRD4 via DCAF16 (BRD4BD2, DC50=1 nM), functions as a molecular glue to recruit DCAF16 selectively to BRD4 BD2, causing degradation of BRD4.

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生物&药学活性

MMH1 is a potent, selective, covalent JQ1-derived PROTAC degrader of BRD4 via DCAF16 (BRD4BD2, DC50=1 nM, Dmax=95%), functions as a molecular glue to recruit DCAF16 selectively to BRD4 BD2, causing degradation of BRD4.

物理化学性质&存储条件

分子量	491.61
分子式	C26H29N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-butyl (S)-2-(4-(4-acrylamidophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

参考文献

1. Li YD, et al. Nat Chem Biol. 2024 Jul 29. doi: 10.1038/s41589-024-01668-4.

MMH1 (BRD4 degrader MMH1)

生物&药学活性

物理化学性质&存储条件

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MMH1 (BRD4 degrader MMH1)

生物&药学活性

物理化学性质&存储条件

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