ML901 | PfYRS inhibitor | Probechem Biochemicals

Chemical Structure : ML901

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ML901 (ML-901)

货号: PC-23600Not For Human Use, Lab Use Only.

ML901 is a potent, specific inhibitor of P. falciparum tyrosine tRNA synthetase (PfYRS, PfTyrRS), shows potent activity against P. falciparum with IC50 of 2.0 nM.

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生物&药学活性

ML901 is a potent, specific inhibitor of P. falciparum tyrosine tRNA synthetase (PfYRS, PfTyrRS), shows potent activity against P. falciparum with IC50 of 2.0 nM.
ML901 targets PfYRS and inhibits protein translation, by a reaction-hijacking mechanism.
ML901 retained activity against all strains of P. falciparum tested, regardless of their resistance profile and geographical origin.
ML901 triggers eIF2α phosphorylation in wildtype P. falciparum (Cam3.II_rev).
ML901 exerts activity against human Atg7 (IC50 = 33 nM), but has much weaker activity against other E1 enzymes.
ML901 single dose (50 mg/kg i.p.) exhibits in vivo antimalarial efficacy oin severe combined immune deficient (SCID) mice, engrafted with P. falciparum infected human RBCs.

物理化学性质&存储条件

分子量	412.32
分子式	C11H14F2N6O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((2R,3S,4R,5R)-5-(4-amino-3-(difluoromethoxy)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl sulfamate

参考文献

1. Xie SC, et al. Science. 2022 Jun 3;376(6597):1074-1079.

2. Xie SC, et al. PLoS Pathog. 2024 Dec 9;20(12):e1012429.

ML901 (ML-901)

生物&药学活性

物理化学性质&存储条件

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ML901 (ML-901)

生物&药学活性

物理化学性质&存储条件

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