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ML471

Chemical Structure : ML471

CAS No.: 2226227-77-4

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ML471 (ML-471)

货号: PC-23599Not For Human Use, Lab Use Only.

ML471 is a potent, selective reaction hijacking inhibitor of P.falciparum tyrosine tRNA synthetase (PfTyrRS, PfYRS), inhibits growth of asexual blood stage P. falciparum (3D7 strain) in a 72-h exposure assay with IC50 of 2.8 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ML471 is a potent, selective reaction hijacking inhibitor of P.falciparum tyrosine tRNA synthetase (PfTyrRS, PfYRS), inhibits growth of asexual blood stage P. falciparum (3D7 strain) in a 72-h exposure assay with IC50 of 2.8 nM.
ML471 has no inhibitory activity against human ubiquitin-activating enzyme (UAE) in vitro.
ML471 exhibits low nanomolar activity against asexual blood stage P. falciparum and potent activity against liver stage parasites, gametocytes and transmissible gametes.
ML471 is well-tolerated and shows single dose oral efficacy in the SCID mouse model of P. falciparum malaria.

物理化学性质&存储条件

分子量 388.40
分子式 C13H20N6O6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

((2R,3S,4R,5R)-5-(4-amino-3-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl sulfamate

参考文献

1. Xie SC, et al. PLoS Pathog. 2024 Dec 9;20(12):e1012429.

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