ML375 |CAS:1488362-55-5 Probechem Biochemicals

Chemical Structure : ML375

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ML375 (VU-0483253, VU0483253)

货号: PC-62746Not For Human Use, Lab Use Only.

ML375 (VU0483253) is a potent, highly selective M5 NAM with submicromolar potency (human M5 IC50=300 nM, rat M5 IC50=790 nM, M1-M4 IC50> 30 uM).

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生物&药学活性

ML375 (VU0483253) is a potent, highly selective M5 NAM with submicromolar potency (human M5 IC50=300 nM, rat M5 IC50=790 nM, M1-M4 IC50> 30 uM).
ML375 exhibts excellent multispecies PK, high CNS penetration, and enantiospecific inhibition.

物理化学性质&存储条件

分子量	424.832
分子式	C23H15ClF2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one

参考文献

1. Gentry PR, et al. J Med Chem. 2013 Nov 27;56(22):9351-5.

2. Berizzi AE, et al. Mol Pharmacol. 2016 Oct;90(4):427-36.

ML375 (VU-0483253, VU0483253)

生物&药学活性

物理化学性质&存储条件

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ML375 (VU-0483253, VU0483253)

生物&药学活性

物理化学性质&存储条件

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