ML304 | PfG6PDH inhibitor | Probechem Biochemicals

Chemical Structure : ML304

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ML304 (ML 304)

货号: PC-20586Not For Human Use, Lab Use Only.

ML304 (ML 304) is a potent, selective inhibitor of Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PDH) with IC50 of 190 nM, with no activity against human G6PD (IC50=80 uM).

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生物&药学活性

ML304 (ML 304) is a potent, selective inhibitor of Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PDH) with IC50 of 190 nM, with no activity against human G6PD (IC50=80 uM).
ML304 inhibits Plasmodium vivax G6PD (PvG6PD) with IC50 of 15.3 uM.
ML304 acts as a competitive inhibitor towards G6P (Ki =0.7 µM) and as a mixed type inhibitor towards NADP+ (Ki =16.3 µM).
ML304 disturbs the cytosolic glutathione-dependent redox potential of P. falciparum blood stage parasites, inhibits P. falciparum 3D7 in the 72 h hypoxanthine incorporation assays with IC50 of 471 nM.

物理化学性质&存储条件

分子量	395.52
分子式	C22H25N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=CC=C(C(N2)=C1)SC3=C(C)C=CC=C3C2=O)NC[C@@H]4N(CC)CCC4

参考文献

1. Maloney P, et al. NIH, Bethesda, MD.

2. Kristina Haeussler, et al. Malar J. 2019 Jan 25;18(1):22.

ML304 (ML 304)

生物&药学活性

物理化学性质&存储条件

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ML304 (ML 304)

生物&药学活性

物理化学性质&存储条件

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