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ML282

Chemical Structure : ML282

CAS No.: 314042-01-8

ML282 (CID 1067700)

货号: PC-62365Not For Human Use, Lab Use Only.

ML282 (CID 1067700) is a competitive small molecule inhibitor of nucleotide binding by Ras-related GTPases, binds the nucleotide binding pocket of Rab7 with Ki value of 13 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML282 (CID 1067700) is a competitive small molecule inhibitor of nucleotide binding by Ras-related GTPases, binds the nucleotide binding pocket of Rab7 with Ki value of 13 nM.
ML282 prevents BODIPY-linked GTP and GDP binding with EC50 values of 11.2 and 21 nM, respectively.
ML282 suppresses T cell-dependent and T cell-independent Ab responses.

物理化学性质&存储条件

分子量 390.472
分子式 C18H18N2O4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-[[(benzoylamino)thioxomethyl]amino]-4,7-dihydro-5,5-dimethyl-5H-thieno[2,3-c]pyran-3-carboxylic acid

参考文献

1. Agola JO, et al. ACS Chem Biol. 2012 Jun 15;7(6):1095-108.

2. Lam T, et al. J Immunol. 2016 Nov 15;197(10):3792-3805.

3. Agola JO, et al. Methods Mol Biol. 2015;1298:331-54.

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