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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-ML276
ML276

Chemical Structure : ML276

CAS No.: 1392138-96-3

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ML276 (ML 276)

货号: PC-20587Not For Human Use, Lab Use Only.

ML276 (ML 276) is a potent, selective inhibitor of Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PDH) with IC50 of 889 nM, with no activity against human G6PD.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ML276 (ML 276) is a potent, selective inhibitor of Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PDH) with IC50 of 889 nM, with no activity against human G6PD.
ML276 inhibits P. falciparum growth in vitro with IC50 values of 2.3 uM for the chloroquine sensitive 3D7 strain and 3.7 uM for the chloroquine resistant Dd2 strain.
ML276 inhibits PfGluPho activity by competing with the substrate.

物理化学性质&存储条件

分子量 425.52
分子式 C23H24FN3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(C1=CC=C(C(NC/2=O)=C1)SC2=C/C3=CC=CC=C3F)NC[C@@H]4N(CC)CCC4

参考文献

1. Preuss J, et al. J Med Chem. 2012 Aug 23;55(16):7262-72.

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