ML141 |CAS:71203-35-5 Probechem Biochemicals

Chemical Structure : ML141

CAS No.: 71203-35-5

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ML141 (ML-141;CID-2950007)

货号: PC-43180Not For Human Use, Lab Use Only.

ML141 (CID-2950007) is a potent, selective, reversible non-competitive inhibitor of Cdc42 GTPase with IC50 of 200 nM in biochemical assays, shows no appreciable inhibitory activity against Rac1, Rab2, Rab7 or Ras.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

ML141 (CID-2950007) is a potent, selective, reversible non-competitive inhibitor of Cdc42 GTPase with IC50 of 200 nM in biochemical assays, shows no appreciable inhibitory activity against Rac1, Rab2, Rab7 or Ras.
ML141 also exhibits IC50 of 2.6 and 5.4 uM for Cdc42 wild type and activated mutant in the primary HTS bead-based assays.
ML141 enhances G-CSF-induced hematopoietic stem and progenitor cell mobilization, also significantly protects neuroblastoma cells from metformin-induced apoptosis.

物理化学性质&存储条件

分子量	407.4854
分子式	C22H21N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 55 mg/mL
Chemical Name/SMILES	Benzenesulfonamide, 4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-

参考文献

1. Surviladze Z, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Chen HY, et al. EMBO Mol Med. 2013 May;5(5):723-36.

3. Zhang Y, et al. Neuroscience. 2015 Mar 19;289:381-91.

4. Chen C, et al. Int J Hematol. 2015 Jan;101(1):5-12.

ML141 (ML-141;CID-2950007)

生物&药学活性

物理化学性质&存储条件

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ML141 (ML-141;CID-2950007)

生物&药学活性

物理化学性质&存储条件

参考文献

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