MK-8825 | CGRP inhibitor | Probechem Biochemicals

Chemical Structure : MK-8825

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MK-8825 (MK8825)

货号: PC-62994Not For Human Use, Lab Use Only.

MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP.

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生物&药学活性

MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP.
MK-8825 blocks hCGRP-stimulated cAMP responses in HEK293 cells stably expressing the human CGRP receptor with IC50 of 0.23 nM.
MK-8825 possesses significantly improved in vivo potency in rat pharmacodynamic models.

物理化学性质&存储条件

分子量	572.617
分子式	C31H30F2N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]-N-[(6S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-3-yl]acetamide

参考文献

1. Bell IM, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3941-5.

2. Michot B, et al. Eur J Pain. 2015 Feb;19(2):281-90.

3. Romero-Reyes M, et al. Exp Neurol. 2015 Sep;271:95-103.

4. Feistel S, et al. J Headache Pain. 2013 Nov 20;14:93.

MK-8825 (MK8825)

生物&药学活性

物理化学性质&存储条件

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MK-8825 (MK8825)

生物&药学活性

物理化学性质&存储条件

参考文献

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