MK-5046 | BRS-3 agonist | Probechem Biochemicals

Chemical Structure : MK-5046

CAS No.: 1022152-70-0

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MK-5046 (MK5046)

货号: PC-38792Not For Human Use, Lab Use Only.

MK-5046 a potent, selective small molecule agonist of BRS-3 (bombesin receptor subtype-3) with Ki and EC50 values of 3.7 and 14 nM (hBRS-3), respectively.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MK-5046 a potent, selective small molecule agonist of BRS-3 (bombesin receptor subtype-3) with Ki and EC50 values of 3.7 and 14 nM (hBRS-3), respectively.
MK-5046 exhibits high selectivity in a screen of >100 receptors, ion channels, and enzymes.
MK-5046 shows potent activities across a range of species, including rat, mouse, dog and rhesus.
MK-5046 causes mechanism-based, dose-dependent reductions in food intake and body weight.

物理化学性质&存储条件

分子量	444.381
分子式	C20H18F6N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-1,1,1-trifluoro-2-[4-(1H-pyrazol-1-yl)phenyl]-3-(4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1H-imidazol-2-yl)propan-2-ol

参考文献

1. Guan XM, et al. J Pharmacol Exp Ther. 2011 Feb;336(2):356-64.

2. Sebhat IK, et al. ACS Med Chem Lett. 2010 Oct 18;2(1):43-7.

MK-5046 (MK5046)

生物&药学活性

物理化学性质&存储条件

参考文献

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MK-5046 (MK5046)

生物&药学活性

物理化学性质&存储条件

参考文献

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