MK-4815 hydrochloride | Falcilysin inhibitor, Antimalarial

Chemical Structure : MK-4815 hydrochloride

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MK-4815 hydrochloride (MK4815 hydrochloride)

货号: PC-23028Not For Human Use, Lab Use Only.

MK-4815 hydrochloride is an orally active small molecule with antimalarial activity, inhibits P. falciparum 3D7 growth with IC50 of 0.03 ug/mL, inhibits falcilysin (FLN) proteolytic activity.

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生物&药学活性

MK-4815 hydrochloride is an orally active small molecule with antimalarial activity, inhibits P. falciparum 3D7 growth with IC50 of 0.03 ug/mL, inhibits falcilysin (FLN) proteolytic activity.
MK-4815 is as potent as chloroquine against the chloroquine-sensitive NF54 strain of P. falciparum (IC50s, 38 and 35 ng/ml, respectively) and more potent than chloroquine against the chloroquine-, pyrimethamine-, and mefloquine-resistant Dd2 strain (IC50s, 40 and 70 ng/ml, respectively).
MK-4815 has broad-spectrum and potent activity against the entire panel, particularly with the potent IC50s for the K1, V1/S, and FCB strains of parasite.
MK-4815 is orally active in a P. berghei mouse model of acute malaria.

物理化学性质&存储条件

分子量	271.83
分子式	C15H26ClNO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-aminomethyl-3,5-di-tert-butylphenol hydrochloride

参考文献

1. Powles MA, et al. Antimicrob Agents Chemother. 2012 May;56(5):2414-9.

2. Wirjanata G, et al. Cell Chem Biol. 2024 Apr 18;31(4):743-759.e8.

MK-4815 hydrochloride (MK4815 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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MK-4815 hydrochloride (MK4815 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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