MK-3207 | CGRP inhibitor | Probechem Biochemicals

Chemical Structure : MK-3207

CAS No.: 957118-49-9

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MK-3207 (MK3207, MK 3207)

货号: PC-42516Not For Human Use, Lab Use Only.

MK-3207 is a highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay.

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
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100 mg		Get quote

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生物&药学活性

MK-3207 is a highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay.
MK-3207 displays >50000-fold selectivity in a panel of 160 enzymes, receptors, channels, and 65-fold more potent than telcagepant; orally bioavailable.

物理化学性质&存储条件

分子量	557.5905
分子式	C31H29F2N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6,9-Diazaspiro[4.5]decane-9-acetamide, 8-(3,5-difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-, (8R)-

参考文献

1. Bell IM, et al. ACS Med Chem Lett. 2010 Jan 12;1(1):24-9.

2. Salvatore CA, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60.

3. Li CC, et al. Br J Clin Pharmacol. 2015 May;79(5):831-7.

MK-3207 (MK3207, MK 3207)

生物&药学活性

物理化学性质&存储条件

参考文献

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MK-3207 (MK3207, MK 3207)

生物&药学活性

物理化学性质&存储条件

参考文献

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