MG-277 | GSPT1 degrader | Probechem Biochemicals

Chemical Structure : MG-277

CAS No.: 2411085-89-5

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MG-277 (MG277)

货号: PC-23062Not For Human Use, Lab Use Only.

MG-277 is a potent molecular glue GSPT1 degrader, effectively degrades GSPT1 protein in a dose- and time-dependent manner in RS4;11 cell line with DC50 of 1.3 nM.

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1 mg	￥5580	In stock
2 mg	￥8980	In stock
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生物&药学活性

MG-277 is a potent molecular glue GSPT1 degrader, effectively degrades GSPT1 protein in a dose- and time-dependent manner in RS4;11 cell line with DC50 of 1.3 nM.
MG-277 is effective against cancer cell lines carrying wild-type, mutated or deleted p53.
MG-277 potently inhibits cell growth in cancer cell lines in a p53-independent manner.
MG-277 is very potent and effective in inhibition of cell growth in both the RS4;11/IRMI-2 and HL-60 leukemia lines, achieving IC50 values of 3.9 nM and 8.3 nM, respectively.

物理化学性质&存储条件

分子量	774.72
分子式	C41H42Cl2FN5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-(5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide

参考文献

1. Jiuling Yang, et al. J Med Chem. 2019 Nov 14;62(21):9471-9487.

MG-277 (MG277)

生物&药学活性

物理化学性质&存储条件

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MG-277 (MG277)

生物&药学活性

物理化学性质&存储条件

参考文献

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