MDEG-541 | MYC PROTAC | Probechem Biochemicals

Chemical Structure : MDEG-541

CAS No.:

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MDEG-541 (MDEG541)

货号: PC-23408Not For Human Use, Lab Use Only.

MDEG-541 is a small molecule MYC PROTAC degrader, induces cereblon-dependent degradation of MYC, GSPT1/2, and PLK1.

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5 mg	￥2380	In stock
10 mg	￥3780	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

MDEG-541 is a small molecule MYC PROTAC degrader, induces cereblon-dependent degradation of MYC, GSPT1/2, and PLK1.
MDEG-541 is based on the MYC-MAX dimerization inhibitor 10058-F4 derivative 28RH and Thalidomide.
MDEG-541 regulates MYC in a fashion dependent on CRBN, ubiquitination, and the proteasome, the compound acts pleiotropic and also decreased the expression of G1 To S Phase Transition 1 (GSPT1), GSPT2, and the Polo-like kinase 1 (PLK1).
MDEG-541 shows cellular activity in conventional gastrointestinal cancer cell lines and primary cancer organoids.

物理化学性质&存储条件

分子量	674.83
分子式	C35H38N4O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-2-(2,6-dioxopiperidin-3-yl)-N-(8-(5-(4-isopropylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)octyl)-1,3-dioxoisoindoline-5-carboxamide

参考文献

1. Lier S, et al. Bioorg Chem. 2022 Feb;119:105505.

MDEG-541 (MDEG541)

生物&药学活性

物理化学性质&存储条件

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MDEG-541 (MDEG541)

生物&药学活性

物理化学性质&存储条件

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