MD-265 | MDM2 PROTAC | Probechem Biochemicals

Chemical Structure : MD-265

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MD-265 (MD265)

货号: PC-23385Not For Human Use, Lab Use Only.

MD-265 is a potent PROTAC MDM2 degrader, potently inhibits RS4;11 cell line with IC50 of 0.7 nM, induces strong p53 activation in cancer cells carrying wild-type p53.

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生物&药学活性

MD-265 is a potent PROTAC MDM2 degrader, potently inhibits RS4;11 cell line with IC50 of 0.7 nM, induces strong p53 activation in cancer cells carrying wild-type p53.
MD-265 potently inhibited cell growth and achieved IC50 values of 0.9 nM to 212 nM in acute leukemia cell lines carrying a wild-type p53.
MD-265 is a potent MDM2 degrader and is >200 times more potent than MI-1063 in cell growth inhibition in the RS4;11 cell line.
MD-265 demonstrated no activity in cancer cells harboring mutated p53.
MD-265 achieved complete and persistent tumor regression in the RS4;11 xenograft model without causing any signs of toxicity.

物理化学性质&存储条件

分子量	921.89
分子式	C50H51Cl2FN6O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-((1R,4R)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)ethynyl)piperidine-1-carbonyl)cyclohexyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide

参考文献

1. Aguilar A, et al. J Med Chem. 2024 Oct 31. doi: 10.1021/acs.jmedchem.4c01818.

MD-265 (MD265)

生物&药学活性

物理化学性质&存储条件

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MD-265 (MD265)

生物&药学活性

物理化学性质&存储条件

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