MBX-4055 | P. falciparum PSAC inhibitor | Probechem Biochemicals

Chemical Structure : MBX-4055

加入收藏

MBX-4055 (MBX4055)

货号: PC-49005Not For Human Use, Lab Use Only.

MBX-4055 is a potent and specific antimalarial compound with IC50 of 42 nM (P. falciparum growth inhibition), acts directly on plasmodial surface anion channel (PSAC, Target K0.5=21 nM) to quantitatively abolish parasite-induced permeability changes.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MBX-4055 is a potent and specific antimalarial compound with IC50 of 42 nM (P. falciparum growth inhibition), acts directly on plasmodial surface anion channel (PSAC, Target K0.5=21 nM) to quantitatively abolish parasite-induced permeability changes.
MBX-4055 is active against divergent human parasite strains, with improved oral absorption with acceptable in vivo tolerability and pharmacokinetics.
MBX-4055 is highly specific for the PSAC target without activity against a battery of human channels, enzymes and receptors, is refractory to acquired resistance during extended in vitro selection.

物理化学性质&存储条件

分子量	418.490
分子式	C17H18N6O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(5-((4-(3-methylpyrazin-2-yl)piperazin-1-yl)sulfonyl)thiophen-2-yl)pyridazin-3(2H)-one

参考文献

1. Michelle M Butler, et al. Mol Pharmacol. 2022 Jul 7;MOLPHARM-AR-2022-000549.

MBX-4055 (MBX4055)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MBX-4055 (MBX4055)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.