MBQ-167 | Rac/Cdc42 inhibitor | Probechem Biochemicals

Chemical Structure : MBQ-167

CAS No.: 2097938-73-1

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MBQ-167 (MBQ 167, MBQ167)

货号: PC-60905Not For Human Use, Lab Use Only.

MBQ-167 (MBQ 167, MBQ167) is a potent, dual Rac/Cdc42 inhibitor with IC50 of 103/78 nM, respectively, in metastatic breast cancer cells.

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10 mg	￥1280	In stock
25 mg	￥1980	In stock
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生物&药学活性

MBQ-167 (MBQ 167, MBQ167) is a potent, dual Rac/Cdc42 inhibitor with IC50 of 103/78 nM, respectively, in metastatic breast cancer cells.
MBQ-167 significantly decreases Rac and Cdc42 downstream effector p21-activated kinase (PAK) signaling and the activity of STAT3, without affecting Rho, MAPK, or Akt activities.
MBQ-167 also inhibits breast cancer cell migration, viability, and mammosphere formation; decreases metastatic cancer cell viability with GI50 of 130 nM without affecting noncancer mammary epithelial cells, and causes G2-M cell-cycle arrest and subsequent apoptosis.
MBQ-167 inhibits mammary tumor growth and metastasis in immunocompromised mice.

物理化学性质&存储条件

分子量	338.414
分子式	C22H18N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-ethyl-3-(5-phenyl-1H-1,2,3-triazol-1-yl)-9H-carbazole

参考文献

1. Humphries-Bickley T, et al. Mol Cancer Ther. 2017 May;16(5):805-818.

MBQ-167 (MBQ 167, MBQ167)

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物理化学性质&存储条件

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MBQ-167 (MBQ 167, MBQ167)

生物&药学活性

物理化学性质&存储条件

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