MAM03055A | Sigma 2 Receptor ligand | Probechem Biochemicals

Chemical Structure : MAM03055A

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MAM03055A (MAM 03055A)

货号: PC-47095Not For Human Use, Lab Use Only.

MAM03055A is a novel bivalent sigma-2 receptor/TMEM97 ligand with cytotoxic activity, exhibits high affinity and strong preference for sigma-2 receptor with Ki of 55.9 nM.

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生物&药学活性

MAM03055A is a novel bivalent sigma-2 receptor/TMEM97 ligand with cytotoxic activity, exhibits high affinity and strong preference for sigma-2 receptor with Ki of 55.9 nM.
MAM03055A displays weak affinity against sigma-1 receptor with Ki of 3371 nM.
MAM03055A potently induced cell death in SK-N-SH neuroblastoma, MDA-MB-231 breast, and both SW48 and SW480 colorectal cancer cell lines, causing proapoptotic BH3 interacting-domain death agonist (BID) cleavage in SK-N-SH cells.
MAM03055A bound pseudo-irreversibly to sigma-2 receptors and caused residual cytotoxic activity after acute exposure and removal of the compound from the media.
MAM03055A also induced a time-dependent loss of sigma-2 receptor/TMEM97 protein from cells.

物理化学性质&存储条件

分子量	810.966
分子式	C43H48F2N8O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-bis(3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)-2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)thiourea

参考文献

1. Liu CZ, et al. Eur J Pharmacol. 2021 Sep 5;906:174263.

MAM03055A (MAM 03055A)

生物&药学活性

物理化学性质&存储条件

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MAM03055A (MAM 03055A)

生物&药学活性

物理化学性质&存储条件

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