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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-M5717
M5717

Chemical Structure : M5717

CAS No.: 1469439-69-7

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M5717 (Cabamiquine, M 5717, DDD107498)

货号: PC-72956Not For Human Use, Lab Use Only.

Cabamiquine (DDD107498, M5717) is a potent, specific P. falciparum translation elongation factor 2 inhibitor (PfeEF2).

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg ￥4280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cabamiquine (DDD107498, M5717) is a potent, specific P. falciparum translation elongation factor 2 inhibitor (PfeEF2).
M5717 demonstrated through high potency against asexual blood-stage P. falciparum parasites as well as in vivo by means of the well-established P. falciparum SCID mouse model.

物理化学性质&存储条件

分子量 462.569
分子式 C27H31FN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-fluoro-2-(4-(morpholinomethyl)phenyl)-N-(2-(pyrrolidin-1-yl)ethyl)quinoline-4-carboxamide

参考文献

1. Arez F, et al. ACS Infect Dis. 2019 Nov 8;5(11):1831-1842.

2. Rottmann M, et al. Antimicrob Agents Chemother. 2020 Mar 24;64(4):e02181-19.

3. McCarthy JS, et al. Lancet Infect Dis. 2021 Dec;21(12):1713-1724.

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