欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Immunology/Inflammation-STING-Licochalcone D
Licochalcone D

Chemical Structure : Licochalcone D

CAS No.: 144506-15-0

加入收藏

Licochalcone D (LicoD)

货号: PC-23577Not For Human Use, Lab Use Only.

Licochalcone D (Lico D) is a lycyrrhiza inflata-derived chalcone, potent and selective STING inhibitor, covalently modifies the Cys148 residue of STING and inhibits STING oligomerization.

规格 价格 库存 数量
2 mg ￥1280 In stock
5 mg ￥1980 In stock
10 mg ￥3280 In stock
25 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Licochalcone D (Lico D) is a lycyrrhiza inflata-derived chalcone, potent and selective STING inhibitor, covalently modifies the Cys148 residue of STING and inhibits STING oligomerization.
Licochalcone D (Lico D) significantly inhibits the degranulation in RBL-2H3 cells with low cytotoxicity.
Licochalcone D (Lico D) significantly inhibited the Ca2+ influx and phosphorylation of extracellular signal regulated kinase (ERK) and MEK.
Licochalcone D (Lico D) inhibits the recruitment of TBK1 and the nuclear translocation of IRF3 and NF-κB.
Licochalcone D (Lico D) ameliorates the inflammatory phenotype in Trex1-1- mice and inhibits the progression of DSS-induced colitis and AOM/DSS-induced colitis-associated colon cancer (CAC).

物理化学性质&存储条件

分子量 354.40
分子式 C21H22O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)prop-2-en-1-one

参考文献

1. Zhang Y, et al. Sci China Life Sci. 2024 Aug 22. doi: 10.1007/s11427-024-2703-6.

2. Tanifuji S, et al. Int Immunopharmacol. 2010 Jul;10(7):769-76.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: