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首页-小分子抑制剂&激动剂-Immunology/Inflammation-MyD88-Lasalocid
Lasalocid

Chemical Structure : Lasalocid

CAS No.: 25999-31-9

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Lasalocid (Lasalocid A, Ionophore X-537A, Lasalocide)

货号: PC-23572Not For Human Use, Lab Use Only.

Lasalocid (Lasalocid A, Lasalocid-A) is a feed additive widely used in ruminant nutrition, selectively induces the degradation of MYD88 in lymphomas harboring the MYD88 L265P mutation, directly binds to the MYD88 L265P protein, enhancing its interaction with the E3 ligase RNF5.

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5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Lasalocid (Lasalocid A, Lasalocid-A) is a feed additive widely used in ruminant nutrition, selectively induces the degradation of MYD88 in lymphomas harboring the MYD88 L265P mutation, directly binds to the MYD88 L265P protein, enhancing its interaction with the E3 ligase RNF5.
Lasalocid A selectively inhibited the viability of lymphoma cells expressing MYD88 L265P and the associated activation of NF-κB.
Lasalocid A promotes MYD88 degradation through the ubiquitin-dependent proteasomal pathway, specifically in lymphomas with the MYD88 L265P mutation.
Lasalocid A exhibits strong antitumor efficacy in xenograft mouse models, induces disease remission in ibrutinib-resistant lymphomas, and shows synergistic activity with the BCL2 inhibitor venetoclax.

物理化学性质&存储条件

分子量 590.80
分子式 C34H54O8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-[(3R,4S,5S,7R)-7-[(2S,3S,5S)-5-ethyl-5-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-3-methyloxolan-2-yl]-4-hydroxy-3,5-dimethyl-6-oxononyl]-2-hydroxy-3-methylbenzoic acid

参考文献

1. Li W, et al. Blood. 2024 Nov 22:blood.2024026781.

2. Basmaeil SM, et al. Front Vet Sci. 2023 Jun 12;10:1181426.

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