LZK PROTAC-21A

Chemical Structure : LZK PROTAC-21A

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货号: PC-23565Not For Human Use, Lab Use Only.

LZK PROTAC-21A is a potent, selective LZK (Leucine zipper-bearing kinase, MAP3K13)-targeting PROTAC with binding affinity of 35 nM.

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生物&药学活性

LZK PROTAC-21A is a potent, selective LZK (Leucine zipper-bearing kinase, MAP3K13)-targeting PROTAC with binding affinity of 35 nM.
PROTAC-21A reduces LZK abundance through a mechanism that involved the ubiquitin-like molecule NEDD8 (Figure 6A) and the proteasome.
PROTAC-21A is selective for DLK/LZK against a broad panel of >450 kinases.
PROTAC-21A induces proteasome-mediated degradation of LZK, targets c-MYC and GOF-p53, and decreases HNSCC viability.

物理化学性质&存储条件

分子量	967.19
分子式	C51H64F2N10O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-2-(8-(4-(2-((4-cyanopyridin-2-yl)amino)-6-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)piperidin-1-yl)-8-oxooctanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

参考文献

1. Funk AL, et al. bioRxiv [Preprint]. 2024 Nov 20:2024.11.19.623840.

LZK PROTAC-21A

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物理化学性质&存储条件

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LZK PROTAC-21A

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