LYG-409 | GSPT1 degrader | Probechem Biochemicals

Chemical Structure : LYG-409

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LYG-409 (LYG409)

货号: PC-23946Not For Human Use, Lab Use Only.

LYG-409 is a potent, selective, and orally bioavailable GSPT1 molecular glue degrader with DC50 of 7.87 nM in KG-1 cells.

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100 mg		Get quote

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生物&药学活性

LYG-409 is a potent, selective, and orally bioavailable GSPT1 molecular glue degrader with DC50 of 7.87 nM in KG-1 cells.
LYG-409 selectively degraded GSPT1 at different concentrations, with minimal effect on other neo-substrates such as IKZF1, IKZF2, SALL4 and CK1α.
LYG-409 exhibits antiproliferative activity on KG-1 cell and MV4–11 cell with IC50 of 10 nM and 8 nM respectively, with little effect on human normal lung epithelial cell BEAS-2B.
LYG-409 degraded GSPT1 in a concentration-dependent manner in AML cell lines MV4–11 and Molm-13 cells, in which the DC50 values of LYG-409 were 16 and 90 nM, respectively.
LYG-409 at 15 mg/kg and 30 mg/kg exhibited antitumor efficacy in a Balb/c nude mouse xenograft MV4–11 AML model.

物理化学性质&存储条件

分子量	515.45
分子式	C25H20F3N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-6-(trifluoromethoxy)-2H-chromene-3-carboxamide

参考文献

1. Zhang Y, et al. J Med Chem. 2025 Jan 24. doi: 10.1021/acs.jmedchem.4c01787.

LYG-409 (LYG409)

生物&药学活性

物理化学性质&存储条件

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LYG-409 (LYG409)

生物&药学活性

物理化学性质&存储条件

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