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首页-小分子抑制剂&激动剂-GPCR-mAChR-LY2033298
LY2033298

Chemical Structure : LY2033298

CAS No.: 886047-13-8

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LY2033298 (LY-2033298, LY 2033298)

货号: PC-60328Not For Human Use, Lab Use Only.

LY2033298 (LY-2033298) is a potent, selective, positive allosteric modulator of muscarinic M4 receptors.

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5 mg ￥1580 In stock
10 mg ￥2380 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LY2033298 (LY-2033298) is a potent, selective, positive allosteric modulator of muscarinic M4 receptors.
LY2033298 directly potentiates agonist binding while having minimal effects on antagonist binding.
LY2033298 enhances inhibition by oxotremorine of light-induced phase shifts in hamster circadian activity rhythms, shows antipsychotic activity in vivo.

物理化学性质&存储条件

分子量 311.784
分子式 C13H14ClN3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methyl-thieno[2,3-b]pyridine-2-carboxamide

参考文献

1. Nawaratne V, et al. Mol Pharmacol. 2008 Oct;74(4):1119-31.

2. Chan WY, et al. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10978-83.

3. Leach K, et al. Neuropsychopharmacology. 2010 Mar;35(4):855-69.

4. Gannon RL, et al. Psychopharmacology (Berl). 2012 Nov;224(2):231-40.

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