LM22B-10

Chemical Structure : LM22B-10

CAS No.: 342777-54-2

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货号: PC-22385Not For Human Use, Lab Use Only.

LM22B-10 is a small moelcule agonist neurotrophin (NT) receptor TrkB and TrkC, selectively binds to and activates TrkB as well as TrkC, shows neurotrophic activitie.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

LM22B-10 is a small moelcule agonist neurotrophin (NT) receptor TrkB and TrkC, selectively binds to and activates TrkB as well as TrkC, shows neurotrophic activitie.
LM22B-10 binds to TrkB-Fc and TrkC-Fc in a dose-dependent manner, but not TrkA-Fc or p75NTR-Fc, displaces BDNF from TrkB and NT-3 from TrkC.
LM22B-10 promotes cell survival preferentially through TrkB and TrkC. LM22B-10, but not BDNF or NT-3, promotes neurite outgrowth in an inhibitory environment.
LM22B-10 selectively induces TrkB, TrkC, AKT and ERK phosphorylation in hippocampal neurons in culture.
LM22B-10 (5 mg/kg IN) penetrates the BBB, and induces TrkB and TrkC phosphorylation and downstream signaling in vivo.

物理化学性质&存储条件

分子量	485.02
分子式	C27H33ClN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[[4-[[4-[Bis-(2-hydroxy-ethyl)-amino]-phenyl]-(4-chloro-phenyl)-methyl]-phenyl]-(2-hydroxy-ethyl)-amino]-ethanol

参考文献

1. Yang T, et al. Neuropharmacology. 2016 Nov;110(Pt A):343-361.

2. Xiang RL, et al. J Cell Physiol. 2020 Jan;235(1):232-244.

LM22B-10

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物理化学性质&存储条件

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LM22B-10

生物&药学活性

物理化学性质&存储条件

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