LM22A-4 |CAS:37988-18-4 Probechem Biochemicals

Chemical Structure : LM22A-4

CAS No.: 37988-18-4

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LM22A-4 (LM22A 4)

货号: PC-61680Not For Human Use, Lab Use Only.

LM22A-4 is a small molecule BDNF mimetic that act as a direct and specific partial agonist of TrkB (EC50=200-500 pM), but not other Trks or p75(NTR).

规格	价格	库存
2 mg (Free Sample)	￥280	In stock
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

LM22A-4 is a small molecule BDNF mimetic that act as a direct and specific partial agonist of TrkB (EC50=200-500 pM), but not other Trks or p75(NTR).
LM22A-4 prevents neuronal degeneration with efficacy equal to that of BDNF in vitro models of neurodegenerative disease.
LM22A-4 causes hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats.
LM22A-4 reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.

物理化学性质&存储条件

分子量	339.34
分子式	C15H21N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	50 mM in DMSO; 100 mM in H2O
Chemical Name/SMILES	N1,N3,N5-tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide

参考文献

1. Simmons DA, et al. J Neurosci. 2013 Nov 27;33(48):18712-27.

2. Massa SM, et al. J Clin Invest. 2010 May;120(5):1774-85.

3. Kajiya M, et al. Int Immunopharmacol. 2014 Apr;19(2):245-52.

LM22A-4 (LM22A 4)

生物&药学活性

物理化学性质&存储条件

参考文献

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LM22A-4 (LM22A 4)

生物&药学活性

物理化学性质&存储条件

参考文献

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