LM11A-31 dihydrochloride | p75NTR ligand | Probechem Biochemicals

Chemical Structure : LM11A-31 dihydrochloride

CAS No.: 1243259-19-9

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LM11A-31 dihydrochloride (LM11A-31 BHS)

货号: PC-61489Not For Human Use, Lab Use Only.

LM11A-31 dihydrochloride is an orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors.

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10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

LM11A-31 dihydrochloride is an orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors.
LM11A-31 shows no effect on nerve growth factor (NGF) binding to TrkA.
LM11A-31 prevents and reverses atrophy of cholinergic neurites, as well as reversing AD pathologies in mid- to late-stage AD mice models.

物理化学性质&存储条件

分子量	316.27
分子式	C12H25N3O2.2HCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S)-2-amino-3-methyl-N-(2-morpholinoethyl)pentanamide dihydrochloride

参考文献

1. Massa SM, et al. J Neurosci. 2006 May 17;26(20):5288-300.

2. Meeker RB, et al. J Neuroimmune Pharmacol. 2012 Jun;7(2):388-400.

3. Simmons DA, et al. PLoS One. 2014 Aug 25;9(8):e102136.

4. Meeker RB, et al. Exp Neurol. 2016 Jan;275 Pt 1:182-98.

LM11A-31 dihydrochloride (LM11A-31 BHS)

生物&药学活性

物理化学性质&存储条件

参考文献

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LM11A-31 dihydrochloride (LM11A-31 BHS)

生物&药学活性

物理化学性质&存储条件

参考文献

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