LLS30 | Galectin-1 inhibitor | Probechem Biochemicals

Chemical Structure : LLS30

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LLS30 (LLS-30)

货号: PC-63369Not For Human Use, Lab Use Only.

LLS30 is a potent, allosteric Galectin-1 (Gal-1) inhibitor, inhibits AR negative cells PC3, DU145, and AR positive cells, 22RV1 and CWR-R1 cells with IC50 of 10.4 μM, 5.3 μM, 3.3 μM and 5.9 μM, respectively.

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生物&药学活性

LLS30 is a potent, allosteric Galectin-1 (Gal-1) inhibitor, inhibits AR negative cells PC3, DU145, and AR positive cells, 22RV1 and CWR-R1 cells with IC50 of 10.4 μM, 5.3 μM, 3.3 μM and 5.9 μM, respectively.
LLS30 decreases Gal-1 binding affinity to its binding partners; showes in vivo efficacy in both AR positive and AR negative xenograft models.
LLS30 not only can potentiate the anti-tumor effect of docetaxel to cause complete regression of tumors, but also effectively inhibit the invasion and metastasis of PCa cells in vivo.

物理化学性质&存储条件

分子量	701.47
分子式	C34H33Cl4N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-(4-(bis(2-hydroxyethyl)amino)phenyl)-1-(3,4-dichlorobenzyl)-1H-benzo[d]imidazol-5-yl)-3-((3,4-dichlorobenzyl)amino)propanamide

参考文献

1. Shih TC, et al. Clin Cancer Res. 2018 Apr 17. pii: clincanres.0157.2018.

LLS30 (LLS-30)

生物&药学活性

物理化学性质&存储条件

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LLS30 (LLS-30)

生物&药学活性

物理化学性质&存储条件

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