LLS2 | Galectin-1 inhibitor | Probechem Biochemicals

Chemical Structure : LLS2

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LLS2 (Galectin-1 inhibitor LLS2)

货号: PC-61647Not For Human Use, Lab Use Only.

LLS2 is a novel potent Galectin-1 (Gal1) inhibitor that decreases membrane-associated H-Ras and K-Ras and contributed to the suppression of pErk pathway.

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生物&药学活性

LLS2 is a novel potent Galectin-1 (Gal1) inhibitor that decreases membrane-associated H-Ras and K-Ras and contributed to the suppression of pErk pathway.
LLS2 kills SKOV3, HT29, PC3, XPA3, MCF7, and A549 with an IC50 of 11.7, 24.5, 28.2, 20.9, 23.2 and 34.3 uM respectively.
LLS2 exhibits synergistic activity against several human cancer cell lines, significantly inhibits the growth of ovarian cancer xenografts in athymic mice combined with paclitaxel.

物理化学性质&存储条件

分子量	809.693
分子式	C40H40Cl2F2N6O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((4-(5-(3-amino-1-((S)-2-amino-3-(3,4-dichlorophenyl)propanamido)-3-oxopropyl)-1-(3,4-difluorobenzyl)-1H-benzo[d]imidazol-2-yl)phenyl)azanediyl)bis(ethane-2,1-diyl) diacetate

参考文献

1. Shih TC, et al. Mol Cancer Ther. 2017 Jul;16(7):1212-1223.

LLS2 (Galectin-1 inhibitor LLS2)

生物&药学活性

物理化学性质&存储条件

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LLS2 (Galectin-1 inhibitor LLS2)

生物&药学活性

物理化学性质&存储条件

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