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首页-抗体药物偶连体和PROTACs-PROTAC-LLC355
LLC355

Chemical Structure : LLC355

CAS No.:

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LLC355 (LLC-355)

货号: PC-22339Not For Human Use, Lab Use Only.

LLC355 is a potent DDR1 degrader and autophagosome-tethering compound (ATTEC) with DC50 of 150.8 nM in NCI-H23 cells, induce DDR1 degradation via lysosome-mediated autophagy, potently suppresses cancer cell tumorigenicity, migration, and invasion.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LLC355 is a potent DDR1 degrader and autophagosome-tethering compound (ATTEC) with DC50 of 150.8 nM in NCI-H23 cells, induce DDR1 degradation via lysosome-mediated autophagy, potently suppresses cancer cell tumorigenicity, migration, and invasion.

物理化学性质&存储条件

分子量 1133.72
分子式 C63H64ClF3N10O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-N-(3-{[4-(2-{2-[(3-{N-[1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl]-4-methylbenzamido}propyl)amino]-2-oxoethoxy}ethyl)piperazin-1-yl]methyl}-5-(trifluoromethyl)phenyl)-4-ethyl-3-(pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide

参考文献

1. Lianchao Liu, et al. J Med Chem. 2024 May 10. doi: 10.1021/acs.jmedchem.4c00162.

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