LL-K8-22 | CDK8 degarder | Probechem Biochemicals

Chemical Structure : LL-K8-22

CAS No.: 3034487-84-5

加入收藏

LL-K8-22 (CDK8 degrader)

货号: PC-20323Not For Human Use, Lab Use Only.

LL-K8-22 is a potent, selective dual degrader of of CDK8 and cyclin C (MDA-MB-468 cell DC50, 2.52 and 2.64 uM), significantly degrades CDK8 without reducing CDK19 and does not degrade other cyclin proteins.

规格	价格	库存
5 mg	￥3580	In stock
10 mg	￥5480	In stock
25 mg	￥8980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

LL-K8-22 is a potent, selective dual degrader of of CDK8 and cyclin C (MDA-MB-468 cell DC50, 2.52 and 2.64 uM), significantly degrades CDK8 without reducing CDK19 and does not degrade other cyclin proteins.
LL-K8-22 showed enhanced anti-proliferative effects over its parental molecule BI-1347.
LL-K8-22 exhibited more pronounced effects on CDK8–cyclin C downstream signaling than BI-1347, suppressing STAT1 phosphorylation more persistently.
LL-K8-22 inhibited E2F- and MYC-driven carcinogenic transcriptional programs.

物理化学性质&存储条件

分子量	573.79
分子式	C37H43N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(3-((3r,5r,7r)-Adamantan-1-yl)propyl)piperazin-1-yl)-2-(4-(4-(isoquinolin-4-yl)phenyl)-1H-pyrazol-1-yl)ethan-1-one

参考文献

1. Mingyu Wang, et al. J Med Chem. 2023 Mar 17. doi: 10.1021/acs.jmedchem.2c02045.

LL-K8-22 (CDK8 degrader)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

LL-K8-22 (CDK8 degrader)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.