LD4172 | RIPK1 degrader | Probechem Biochemicals

Chemical Structure : LD4172

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LD4172 (LD-4172)

货号: PC-22126Not For Human Use, Lab Use Only.

LD4172 is a first-in-class RIPK1 PROTAC degrader with DC50 values of 4-400 nM in a panel of human and mouse cancer cell lines.

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生物&药学活性

LD4172 is a first-in-class RIPK1 PROTAC degrader with DC50 values of 4-400 nM in a panel of human and mouse cancer cell lines.
LD4172 is a potent RIPK1 degrader with rapid and sustained effects in vitro.
LD4172 (1 uM) acheives >90% of RIPK1 degradation within 2 and 4 h in Jurkat and B16F10 cells, respectively.
LD4172 sensitizes B16F10 cells to TNFα-mediated apoptosis.
LD4172 induces immunogenic cell death (ICD) and enriches tumor-infiltrating lymphocytes and substantially sensitizes the tumors to anti-PD1 therapy.

物理化学性质&存储条件

分子量	1149.39
分子式	C61H75F3N10O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(3-(4-amino-5-(1-(2-(3-(trifluoromethoxy)phenyl)acetyl)indolin-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)-N12-((S)-1-((2S,4R)-4-hydroxy-2-(((R)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)dodecanediamide

参考文献

1. Xin Yu, et al. bioRxiv. 2024 Mar 29:2024.03.25.586133.

LD4172 (LD-4172)

生物&药学活性

物理化学性质&存储条件

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LD4172 (LD-4172)

生物&药学活性

物理化学性质&存储条件

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