LD-110 | LSD1 PROTAC | Probechem Biochemicals

Chemical Structure : LD-110

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LD-110 (LD110)

货号: PC-25869Not For Human Use, Lab Use Only.

LD-110 is a potent and efficacious PROTAC) degrader of LSD1 with DC50 of 0.44, 1.18, and 1.24 μM in the KYSE-150, KYSE-30, and EC9706, respectively.

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生物&药学活性

LD-110 is a potent and efficacious PROTAC) degrader of LSD1 with DC50 of 0.44, 1.18, and 1.24 μM in the KYSE-150, KYSE-30, and EC9706, respectively.
LD-110 shows no effect on CoREST, HDAC1, and HDAC2 protein levels.
LD-110 effectively suppresses the growth of ESCC cells with half-maximal inhibitory concentration (IC50) values of 3.94, 3.35, and 3.08 μM in KYSE-150, KYSE-30, and EC9706, respectively.
LD-110 induces both early-stage and late-stage apoptosis in a dose-dependent manner in both KYSE-30 and EC9706 cells.
LD-110 (1-10 uM) effectively induces apoptosis in the ESCC KYSE-30 cells.
LD-110 dose-dependently inhibited the tumor growth at both 30 and 100 mg/kg via intraperitoneal (IP) administration without any effect on body weight in KYSE-150 xenograft tumor models.

物理化学性质&存储条件

分子量	794.95
分子式	C47H50N6O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5-((1-(9-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)nonanoyl)piperidin-4-yl)methoxy)-2-(p-tolyl)pyridin-3-yl)benzonitrile

参考文献

1. Zhuo J, et al. J Med Chem. 2025 Oct 23;68(20):21860-21877.

LD-110 (LD110)

生物&药学活性

物理化学性质&存储条件

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LD-110 (LD110)

生物&药学活性

物理化学性质&存储条件

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