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首页-抗体药物偶连体和PROTACs-PROTAC-LAG-3 PROTAC-1
LAG-3 PROTAC-1

Chemical Structure : LAG-3 PROTAC-1

CAS No.:

LAG-3 PROTAC-1

货号: PC-25871Not For Human Use, Lab Use Only.

LAG-3 PROTAC-1 is a potent, efficacious PROTAC) degrader of immune checkpoint receptor lymphocyte activation gene-3 (LAG-3) with DC50 of 0.27 uM in Raji-LAG3 cells (24 h).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LAG-3 PROTAC-1 is a potent, efficacious PROTAC) degrader of immune checkpoint receptor lymphocyte activation gene-3 (LAG-3) with DC50 of 0.27 uM in Raji-LAG3 cells (24 h).

物理化学性质&存储条件

分子量 608.70
分子式 C34H36N6O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3R,4S)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)-4-phenyl-1-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamide

参考文献

1. Vázquez NG, et al. Bioorg Med Chem Lett. 2025 Oct 4;130:130428.

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