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首页-抗体药物偶连体和PROTACs-PROTAC-KYH1872
KYH1872

Chemical Structure : KYH1872

CAS No.:

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KYH1872 (KYH 1872, KYH-1872)

货号: PC-21045Not For Human Use, Lab Use Only.

KYH1872 is a PROTAC that induces protein degradation via the KLHDC2 E3 ubiquitin ligase, KYH1872 is consisted of a C-terminal fragment of the SelK protein and promiscuous kinase inhibitor YHJ1039 via PGE linker.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KYH1872 is a PROTAC that induces protein degradation via the KLHDC2 E3 ubiquitin ligase, KYH1872 is consisted of a C-terminal fragment of the SelK protein and promiscuous kinase inhibitor YHJ1039 via PGE linker.
KYH1872 induces the degradation of NEK9, FAK, CDK4, CDK6, and WEE1 in cells treated with 1 and 10 μM compound for 24 h.
KYH1872 binds to the KLHDC2 protein with Kd of <2 nM.

物理化学性质&存储条件

分子量 1248.50
分子式 C57H77N13O13S3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Younghoon Kim, et al. Cell Chem Biol. 2023 Aug 5;S2451-9456(23)00236-2.

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