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首页-抗体药物偶连体和PROTACs-PROTAC-KTX-951
KTX-951

Chemical Structure : KTX-951

CAS No.: 2573298-36-7

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KTX-951 (KTX951 )

货号: PC-26139Not For Human Use, Lab Use Only.

KTX-951 is a potent and orally active degrader of IRAK4 and the Ikaros and Aiolos (IMiD) substrates with DC50 of 13 nM, 14 nM and 13 nM for IRAK4, Ikaros and Aiolos, respectively, induces proteasomal degradation of these key proteins, leading to the dual inhibition of the NF-κB and IRF4 signaling pathways.

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5 mg ￥8980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KTX-951 is a potent and orally active degrader of IRAK4 and the Ikaros and Aiolos (IMiD) substrates with DC50 of 13 nM, 14 nM and 13 nM for IRAK4, Ikaros and Aiolos, respectively, induces proteasomal degradation of these key proteins, leading to the dual inhibition of the NF-κB and IRF4 signaling pathways.

物理化学性质&存储条件

分子量 850.97
分子式 C46H52F2N8O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(1,1-Difluoroethyl)-N-(2-(trans-4-((2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-7-azaspiro[3.5]nonan-7-yl)methyl)cyclohexyl)-6-methoxy-2H-indazol-5-yl)picolinamide

参考文献

1. Walker D H, et al. Cancer Research, 2020, 80(16_Supplement): 5222-5222.

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