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首页-抗体药物偶连体和PROTACs-PROTAC-KTX-582
KTX-582

Chemical Structure : KTX-582

CAS No.: 2573298-13-0

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KTX-582 (KTX582)

货号: PC-26138Not For Human Use, Lab Use Only.

KTX-582 is a potent, selective IRAK4 PROTAC degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively, induces apoptosis in MYD88MT DLBCL, induces in vivo tumor regressions in lymphoma model.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KTX-582 is a potent, selective IRAK4 PROTAC degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively, induces apoptosis in MYD88MT DLBCL, induces in vivo tumor regressions in lymphoma model.

物理化学性质&存储条件

分子量 872.95
分子式 C45H51F3N8O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(trans-4-(((3-(trans-3-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)cyclobutoxy)propyl)(methyl)amino)methyl)cyclohexyl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide

参考文献

1. Patent WO/2020/113233.

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