KNX-115 (KNX115)

Chemical Structure : KNX-115

加入收藏

货号: PC-49323Not For Human Use, Lab Use Only.

KNX-115 (KNX115) is a potent, selective inhibitor of plasmodium falciparum myosin A (PfMyoA), inhibits PfMyoA actin-activated ATPase with Ki of 17 nM, inhibits full-length PfMyoA with IC50 of <40 nM in in vitro actin-activated myosin ATPase assay.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

KNX-115 (KNX115) is a potent, selective inhibitor of plasmodium falciparum myosin A (PfMyoA), inhibits PfMyoA actin-activated ATPase with Ki of 17 nM, inhibits full-length PfMyoA with IC50 of <40 nM in in vitro actin-activated myosin ATPase assay.
KNX-115 shows >50-fold selectivity against cardiac, skeletal, and smooth muscle myosins.
KNX-115 inhibits the blood and liver stages of Plasmodium with an EC50 of 110 nM, with negligible liver cell toxicity.
KNX-115 inhibits sporozoite cell traversal and blocks the gametocyte to oocyst conversion in the mosquito.
KNX-115 displays a similar killing profile to pyrimethamine and parasites are totally killed after 96 hours of treatment.
KNX-115 is equally effective at inhibiting a panel of Plasmodium strains resistant to experimental and marketed antimalarials.

物理化学性质&存储条件

分子量	349.42
分子式	C15H15N3O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-methoxy-N-((3-(thiophen-2-yl)-1H-pyrazol-4-yl)methyl)benzenesulfonamide

参考文献

1. Trivedi DV, et al. Proc Natl Acad Sci U S A. 2026 Jul 28;123(30):e2608709123.

KNX-115 (KNX115)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

KNX-115 (KNX115)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.