欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-KNX-002
KNX-002

Chemical Structure : KNX-002

CAS No.: 1029644-35-6

加入收藏

KNX-002 (KNX002)

货号: PC-49324Not For Human Use, Lab Use Only.

KNX-002 (KNX002) is a potent, specific inhibitor of Toxoplasma gondii class XIV myosin TgMyoA, inhibits TgMyoA ATPase activity with IC50 of 2.8 uM, shows little to no effect on any of the vertebrate myosins.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    KNX-002 (KNX002) is a potent, specific inhibitor of Toxoplasma gondii class XIV myosin TgMyoA, inhibits TgMyoA ATPase activity with IC50 of 2.8 uM, shows little to no effect on any of the vertebrate myosins.
    KNX-002 has little to no detectable effect on the actin-activated ATPase activity of bovine cardiac myosin, chicken gizzard smooth muscle myosin, rabbit fast skeletal muscle myosin, or bovine slow skeletal muscle myosin at 40 uM.
    KNX-002 inhibits parasite motility and growth in culture in a dose-dependent manner (IC50=19.7 uM), with no detectable toxicity to human cells.
    The mutation TgMyoA (T130A) renders the motor less sensitive to KNX-002, parasites expressing the T130A mutation shows reduced sensitivity to KNX-002 in both motility and growth assays.

    物理化学性质&存储条件

    分子量 325.430
    分子式 C18H19N3OS
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[1-(4-Methoxyphenyl)cyclopropyl]-3-(2-thienyl)-1H-pyrazole-4-methanamine

    参考文献

    1, Moussaoui D, et al. Nat Commun. 2023 Jun 12;14(1):3463.

    备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    联系我们 sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    询单

    • *产品名称:
    • *姓名:
    • *邮箱:
    • *公司名称:
    • *询单数量:
    • *国籍:
    • 询单信息: